Liquid Biopsy · @Liquid_Biopsy
3rd Mar 2015 from TwitLonger
$CYCC Abstract Bodies for #AACR15 meeting:
1 Tyrosyl-DNA phosphodiesterase 1 (TDP1) is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside antimetabolite in clinical trials targeted to ATM- and BRCA-deficient tumors? 2 FANCA protein is involved in the homologous recombination repair of sapacitabine-induced DNA damage?
3 Brca1-deficient ovarian cancer cells are sensitized to the DNA-strand-breaking nucleoside analog sapacitabine that synergizes with PARP inhibition ?
4 Novel CDK2/9 inhibitor has antineoplastic activity in lung cancer by inducing anaphase catastrophe ? jboyll has joined.?
5 CYC065, a novel CDK2/5/9 inhibitor: detailed mechanistic studies, determinants of sensitivity and synergistic combinations
6 Targeting low molecular weight (LMW) cyclin E-Cdk2 pathway for the prevention of breast cancer
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sapacitabine seliciclib cyc065 cyc202 cyc682 roscovitine